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KMID : 0361420070310020202
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Journal of Korean Academy of Rehabilitation Medicine
2007 Volume.31 No. 2 p.202 ~ p.206
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Effects of Growth Hormone Replacement Therapy on Quality of Life in Patients with Somatopause
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Kim Sang-Beom
Yoon Ki-Sung
Lee Kyeong-Woo
Kwak Hyun
Ryoo Kyung-Hyun
Park Kyoo-Tae
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Abstract
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Objective: There is increasing interest in growth hormone (GH) replacement therapy to improve quality of life (QoL) of elderly with age-related decline in GH level (somatopause). The aim of this study was to evaluate the effect of GH replacement on the QoL in patients with somatopause.
Methods: A prospective study of 56 adults with somatopause was conducted. They were replaced with a GH over a 6-month period. QoL was assessed by using three self-rating questionnaires: the Nottingham Health Profile (NHP), the Psychological General Well-Being Index (PGWBI) and theAssessment of Growth Hormone Deficiency in Adults (AGHDA).
Results: Significant impairment in QoL as measured by NHP, PGWBI and AGHDA were noted in patients with somatopause compared with age and sex matched normal population (p<0.05). There was significant improvement in QoL after 6-month of GH replacement (p<0.05).
Conclusion: Six months GH replacement induced an improvement in the QoL of patients with somatopause.
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KEYWORD
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Somatopause, Quality of Life, Growth Hormone Replacement Therapy
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